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  • Title: Synthesis of (-)-paroxetine via enantioselective phase-transfer catalytic monoalkylation of malonamide ester.
    Author: Kim MH, Park Y, Jeong BS, Park HG, Jew SS.
    Journal: Org Lett; 2010 Jun 18; 12(12):2826-9. PubMed ID: 20499863.
    Abstract:
    A new enantioselective synthetic method of (-)-paroxetine is reported. (-)-Paroxetine could be obtained in 15 steps (95% ee and 9.1% overall yield) from N,N-bis(p-methoxyphenyl)malonamide tert-butyl ester via the enantioselective phase-transfer catalytic alkylation and the diastereoselective Michael addition as the key steps.
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