These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Emerging therapies in relapsing-remitting multiple sclerosis.
    Author: Marriott JJ, O'Connor PW.
    Journal: Rev Recent Clin Trials; 2010 Sep; 5(3):179-88. PubMed ID: 20500147.
    Abstract:
    Disease modifying therapy (DMT) first became available for relapsing-remitting multiple sclerosis (RRMS) fifteen years ago with the development of the moderately effective injectable agents interferon (IFN)-beta and glatiramer acetate (GA). The subsequent licensure of mitoxantrone (MX) and natalizumab (NZ) has allowed for better control of refractory disease at the expense of potentially life-threatening side effects in a minority of patients. This dichotomy between DMT potency and safety also characterizes the next generation of DMTs. Five oral medications (fingolimod, cladribine, teriflunomide, laquinimod and fumarate) are at various stages of phase III trials and it is anticipated that at least some of these will be on the market within the next year. The development of oral agents would be a tremendous advance with respect to convenience and it is anticipated that this would dramatically increase the number of patients on therapy. In parallel with oral therapies, powerful immunosuppressive monoclonal antibodies (alemtuzumab, rituximab/ocrelizumab, daclizumab) are also being evaluated. Enthusiasm for the next generation of therapies is tempered by safety concerns. Serious and occasionally fatal complications have occurred with the emerging monoclonal therapies and rigorous patient selection will be required for these agents. Moreover, some of the oral DMTs that are most eagerly awaited by patients have also been associated with serious side-effects in the trials to date. It is unclear how oral agents will be incorporated into future treatment algorithms given the need to weigh the ease of oral administration against the relative inconvenience but long-term safety of current first-line injectable therapies.
    [Abstract] [Full Text] [Related] [New Search]