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  • Title: Calcitonin increases the inhibitory effect of opioids in guinea-pig ileum.
    Author: Martin MI, Colado MI, Alfaro MJ.
    Journal: Gen Pharmacol; 1991; 22(1):73-5. PubMed ID: 2050289.
    Abstract:
    1. The relationship between salmon calcitonin (S-CT) and opioid system was studied in isolated guinea-pig ileum. 2. Addition of S-CT (0.1 to 1.6 U/ml) to the organ bath did not modify the amplitude of the contractile response induces by electrical stimulation. 3. However, when tissues were incubated 30 min with S-CT (0.1 U/ml), the inhibitory effect of the release of endogenous opioids, met-enkephalin (1 microM) and morphine (0.2 microM) was significantly increased. 4. Our results suggest that some of the analgesic effects of S-CT could be attributed to an up-regulation of the opioid receptors.
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