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  • Title: Compassionate use of intravitreal pegaptanib in patients with age-related macular degeneration.
    Author: Ricci F, Missiroli F, Cedrone C, Grossi M, Regine F.
    Journal: Semin Ophthalmol; 2010; 25(1-2):16-20. PubMed ID: 20507192.
    Abstract:
    The study aim was to evaluate the short-term safety and efficacy of pegaptanib sodium injections (Macugen, Eyetech Pharmaceuticals, Inc., New York, NY) in the compassionate-use therapy of choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD). Intravitreal pegaptanib was used to treat 41 eyes in 40 patients with CNV. Injections were given every 6 weeks, and a minimum of three injections were planned. The mean change in BCVA for all lesions was a loss of 0.03 Snellen lines. Seven eyes (17.1%) gained more than 3 lines, three (7.31%) lost 6 lines or more, and in 75.6% the BCVA stabilized or improved.
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