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  • Title: Cytotoxic activity of trijugin-type limonoids from Cipadessa baccifera.
    Author: Ning J, Di YT, Wang YY, He HP, Fang X, Li Y, Li SL, Hao XJ.
    Journal: Planta Med; 2010 Nov; 76(16):1907-10. PubMed ID: 20509106.
    Abstract:
    Two new trijugin-type limonoids, cipatrijugins E and F (1 and 2), together with the known cipatrijugins A and D (3-4), were isolated from the stem bark of Cipadessa baccifera. All structures were elucidated by spectroscopic analysis. The in vitro cytotoxicity of compounds 1-4 was also tested. Compound 1 showed significant in vitro cytotoxicity against MCF-7, SW480, HL-60, and SMMC-7721 cells, with IC(50) values of 5.0, 6.6, 4.5, and 21.6 µM, respectively.
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