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  • Title: Asymmetric catalytic aziridination of cyclic enones.
    Author: De Vincentiis F, Bencivenni G, Pesciaioli F, Mazzanti A, Bartoli G, Galzerano P, Melchiorre P.
    Journal: Chem Asian J; 2010 Jul 05; 5(7):1652-6. PubMed ID: 20512797.
    Abstract:
    The first catalytic method for the asymmetric aziridination of cyclic enones is described. The presented organocatalytic strategy is based on the use of an easily available organocatalyst that is able to convert a wide range of cyclic enones into the desired aziridines with very high enantiomeric purity and good chemical yield. Such a method may very well open up new opportunities to stereoselectively prepare complex chiral molecules that possess an indane moiety, a framework that is found in a large number of bioactive and pharmaceutically important molecules.
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