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  • Title: Flow-enhanced off-resonance saturation for remote detection of iron-based contrast agents.
    Author: Krämer P, Helluy X, Kampf T, Lang E, Jakob PM.
    Journal: Magn Reson Med; 2010 Jun; 63(6):1708-15. PubMed ID: 20512876.
    Abstract:
    A switchable contrast mechanism, flow enhanced off-resonance saturation, is presented. This technique combines the effects of flow and off-resonance saturation for remote detection of iron oxide contrast agents incorporated into a vessel wall. Initial results from phantom experiments are presented and show the feasibility of this method. A specific saturation contrast could be observed. This contrast mechanism is highly dependent on field homogeneity and spectral selectivity of the off-resonance saturation pulses. The contrast scales directly with the pulse offset of the used saturation pulses, the flow velocity in the vessel, and the duration of the off-resonance saturation module prior to the imaging sequence. This technique has the potential to detect iron-loaded atherosclerotic plaques in future in vivo applications.
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