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  • Title: A highly effective gene delivery vector--hyperbranched poly(2-(dimethylamino)ethyl methacrylate) from in situ deactivation enhanced ATRP.
    Author: Newland B, Tai H, Zheng Y, Velasco D, Di Luca A, Howdle SM, Alexander C, Wang W, Pandit A.
    Journal: Chem Commun (Camb); 2010 Jul 14; 46(26):4698-700. PubMed ID: 20514386.
    Abstract:
    A hyperbranched 2-(dimethylamino)ethyl methacrylate (DMAEMA) based polymer has been synthesised by a one-pot in situ deactivation enhanced atom transfer radical polymerisation (DE-ATRP); it exhibits much higher transfection ability than linear poly(DMAEMA) and is comparable to the well known branched poly(ethylene imine) (PEI) and the SuperFect dendrimer but with lower cytotoxicity.
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