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  • Title: Serum albumin as a marker for disease activity in patients with systemic lupus erythematosus.
    Author: Yip J, Aghdassi E, Su J, Lou W, Reich H, Bargman J, Scholey J, Gladman DD, Urowitz MB, Fortin PR.
    Journal: J Rheumatol; 2010 Aug 01; 37(8):1667-72. PubMed ID: 20516026.
    Abstract:
    OBJECTIVE: To determine whether serum albumin reflects disease activity in patients with systemic lupus erythematosus (SLE) with and without nephritis (LN, LNN), and whether serum albumin could be a surrogate marker of SLE disease activity overall. There is currently no clinical "gold standard" in the assessment of disease activity in SLE. METHODS: Patients with >or= 3 clinic visits within a maximum followup period of 10 years were selected from the University of Toronto Lupus Clinic database. Subjects were divided into 3 groups: LN-B, those with nephritis defined by histological findings on renal biopsies; LN-L, those with nephritis defined by laboratory abnormalities in the absence of biopsy; and LNN, those without nephritis. In a subanalysis, the renal groups were further stratified by proteinuria status. The associations of SLE-Disease Activity Index (SLEDAI-2K) with serum albumin and dsDNA were examined using the mixed model regression analysis. RESULTS: A total of 1078 patients were studied: 89.1% female, 71.5% white, mean age 33.6 (SD 12.6) years, and with median baseline SLEDAI-2K of 8. Serum albumin was more significantly associated with SLEDAI in LN-B and LN-L. The association was also present but weaker in the LNN group. In all LN, the associations between serum albumin and SLEDAI-2K were stronger in those with proteinuria. CONCLUSION: In patients with SLE, higher SLEDAI was associated with lower serum albumin levels.
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