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  • Title: TRIM8 modulates STAT3 activity through negative regulation of PIAS3.
    Author: Okumura F, Matsunaga Y, Katayama Y, Nakayama KI, Hatakeyama S.
    Journal: J Cell Sci; 2010 Jul 01; 123(Pt 13):2238-45. PubMed ID: 20516148.
    Abstract:
    TRIM8 is a member of the protein family defined by the presence of a common domain structure composed of a tripartite motif: a RING-finger, one or two B-box domains and a coiled-coil motif. Here, we show that TRIM8 interacts with protein inhibitor of activated STAT3 (PIAS3), which inhibits IL-6-dependent activation of STAT3. Ectopic expression of TRIM8 cancels the negative effect of PIAS3 on STAT3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus. Furthermore, expression of TRIM8 in NIH3T3 cells enhances Src-dependent tumorigenesis. These findings indicate that TRIM8 enhances the STAT3-dependent signal pathway by inhibiting the function of PIAS3.
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