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  • Title: Comparison of permissive hypotensive resuscitation, low-volume fluid resuscitation, and aggressive fluid resuscitation therapy approaches in an experimental uncontrolled hemorrhagic shock model.
    Author: Durusu M, Eryilmaz M, Oztürk G, Menteş O, Ozer T, Deniz T.
    Journal: Ulus Travma Acil Cerrahi Derg; 2010 May; 16(3):191-7. PubMed ID: 20517741.
    Abstract:
    BACKGROUND: In this study, we aimed to compare the efficacy of aggressive fluid resuscitation, low-volume fluid resuscitation and permissive hypotensive resuscitation in an experimental uncontrolled hemorrhagic shock model. METHODS: Forty-four male Guinea pigs were used in the study in an experimental uncontrolled shock model. Guinea pigs were split into six groups including normovolemic-normotensive fluid treatment group, normovolemic-permissive hypotensive fluid treatment group, low-volume normotensive fluid treatment group, low-volume permissive hypotensive fluid treatment group, no treatment (n=6), and sham-operated groups (n=6). Resuscitation was initiated when mean arterial pressure (MAP) reached 30 mmHg. In the permissive hypotensive resuscitation group, fluid treatment continued until MAP reached 45+/-5 mmHg and in the aggressive fluid groups until MAP reached 60+/-5 mmHg. Resuscitation fluid was hetastarch 6% (hydroxyethyl starch) in the low-volume fluid groups and Ringer's lactate in the normovolemic fluid groups. RESULTS: Mean survival time was 122.75+/-4.83 min in the normovolemic-normotensive fluid group, 130.87+/-16.31 min in the normovolemic-permissive hypotensive group, 122.12+/-11.53 min in the low-volume-normotensive fluid group, and 152.25+/-9.10 min in the low-volume-permissive hypotensive fluid group. Survival time was found significantly higher in the group in which low-volume-permissive hypotensive fluid treatment was applied than in the other groups. CONCLUSION: When pressure effect was compared during treatment, permissive-hypotensive resuscitation was found more effective in both groups that received colloid and crystalloid treatment.
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