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  • Title: Progesterone does not affect cocaine-induced conditioned place preference or locomotor activity in male rats.
    Author: Russo SJ, Sun WL, Minerley AC, Weierstall K, Nazarian A, Festa ED, Niyomchai T, Akhavan A, Jenab S, Quiñones-Jenab V.
    Journal: Ethn Dis; 2010; 20(1 Suppl 1):S1-73-7. PubMed ID: 20521389.
    Abstract:
    INTRODUCTION: The present study aimed to determine if, as occurs in female rats, progesterone attenuates cocaine-induced reward and psychomotor responses in male rats. METHODS: The role of progesterone in the acquisition and/or expression of cocaine-induced conditioned place preference (CPP) and locomotor responses of intact male rats was studied. For chronic progesterone treatment, rats received Silastic capsules with either progesterone (100%) or vehicle 1 week prior to conditioning. For acute progesterone treatment, rats received subcutaneous injections of progesterone (500 microg) or vehicle (sesame oil) 4 hours before intraperitoneal injections of saline or cocaine administration (20 mg/kg) on conditioning days (acquisition phase-formation of reward associations) or before testing (expression phase-recall of reward associations). RESULTS: Both progesterone-treatment paradigms produced equivalent progesterone serum levels. Progesterone administered chronically or acutely during the acquisition and expression phases of cocaine conditioning did not block cocaine-induced CPP. Nor did progesterone affect ambulatory or rearing behaviors after cocaine administration. CONCLUSION: These results suggest that, unlike the findings with female rats (in which similar treatment paradigms inhibited the formation and recall of cocaine-induced CPP), progesterone plays a limited role in the cocaine-induced reward or psychomotor responses of male rats.
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