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  • Title: Sex differences in dopamine D2-like receptor-mediated G-protein activation in the medial prefrontal cortex after cocaine.
    Author: Sun WL, Festa ED, Jenab S, Quinones-Jenab V.
    Journal: Ethn Dis; 2010; 20(1 Suppl 1):S1-88-91. PubMed ID: 20521392.
    Abstract:
    INTRODUCTION: Sexually dimorphic behavioral responses to cocaine have been linked to a difference in activation of dopamine receptors. Our study was conducted to determine whether dopamine D2-like receptor-activated G-protein contributes to sex differences in response to cocaine in the medial prefrontal cortex (mPFC). METHOD: In vitro functional autoradiography was performed using dopamine receptor D2 agonist (quinpirole, 100 microM) to stimulate [35S]GTPgammaS binding in brain tissue sections from male and female Fischer rats treated with saline (1 mL/kg) or cocaine (20 mg/kg; i.p.). RESULTS: Overall, quinpirole increased G-protein activation in the caudate-putamen, nucleus accumbens, and frontal cortex in both sexes. Although saline-treated male rats had higher [35S]GTPyS binding in the mPFC than their female counterparts, cocaine-treated females had higher [35S]GTPgammaS binding in the mPFC than cocaine-treated males. CONCLUSIONS: These data suggest that both intrinsic and activational effects of dopamine D2-like receptor-mediated G-protein activation in the mPFC may contribute to the differences between males and females in their response to acute cocaine administration.
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