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  • Title: Cytotoxic ent-kaurane diterpenoids from Isodon rubescens var. lushiensis.
    Author: Luo X, Pu JX, Xiao WL, Zhao Y, Gao XM, Li XN, Zhang HB, Wang YY, Li Y, Sun HD.
    Journal: J Nat Prod; 2010 Jun 25; 73(6):1112-6. PubMed ID: 20521771.
    Abstract:
    Ten new ent-kaurane diterpenoids, isolushinins A-J (1-10), together with 20 known compounds, were isolated from the aerial parts of Isodon rubescens var. lushiensis. The structures of 1-10 were elucidated by spectroscopic analysis. Several of the compounds isolated were evaluated for their cytotoxicity against the HL-60, SMMC-7721, A-549, SK-BR-3, and PANC-1 human cancer cell lines, and some exhibited quite potent inhibitory activities.
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