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  • Title: Copper-catalyzed amination of alkenyl halides: efficient method for the synthesis of enamines.
    Author: Wang Y, Liao Q, Xi C.
    Journal: Org Lett; 2010 Jul 02; 12(13):2951-3. PubMed ID: 20521777.
    Abstract:
    A copper-catalyzed method for the coupling of alkenyl halides with secondary amines has been developed. This protocol used a combination of 10 mol % copper iodide and 20 mol % N,N'-dimethylethane-1,2-diamine as catalyst. The reaction proceeded with various aromatic amines and alkenyl bromides or alkenyl iodides, and the enamines were formed in high yields with excellent regioselectivity and stereoselectivity under the reaction conditions.
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