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  • Title: Specific release of plasma membrane enzymes by a phosphatidylinositol-specific phospholipase C.
    Author: Low MG, Finean JB.
    Journal: Biochim Biophys Acta; 1978 Apr 20; 508(3):565-70. PubMed ID: 205248.
    Abstract:
    The release of plasma membrane ecto-enzymes by a phosphatidylinositol-specific phospholipase C from Staphylococcus aureus was investigated. There was no effect on L-leucyl-beta-naphthylamidase, alkaline phosphodeisterase I and Ca2+- or MG2+-ATPase, but substantial proportions of the alkaline phosphatase and 5-nucleotidase were released. There was no simultaneous release of phospholipid and the solubilized enzymes were not exluded from Sepharose 6-B. It was therefore concluded that release was not a secondary consequence of membrane vesiculation but occurred as a result of the disruption of specific interactions involving the phosphatidylinositol molecule.
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