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  • Title: Induction of hepatic cytochrome P-450 and drug metabolism by doxapram in the mouse.
    Author: Ishikawa M, Ozaki M, Takayanagi Y, Sasaki K.
    Journal: Res Commun Chem Pathol Pharmacol; 1991 Apr; 72(1):109-12. PubMed ID: 2052744.
    Abstract:
    The ability of doxapram (20 mg/kg, i.p. daily for 5 days) to induce hepatic cytochrome P-450 and xenobiotic metabolism was examined in male mice. Compared with the control values, the doxapram treatment significantly increased the amount of cytochrome P-450, and activities of aminopyrine N-demethylase, ethylmorphine N-demethylase and meperidine N-demethylase. In contrast, there were no changes in the activities of aniline hydroxylase, 7-ethoxycoumarine deethylase, NADPH-cytochrome c reductase and NADH-ferricyanide reductase, and cytochrome b5 content. These data show that there is a substrate specificity in the ability of doxapram to induce the hepatic drug metabolism in male mice.
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