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  • Title: [The immunotropic activity of lupane and oleanane 2,3-seco-triterpenoids].
    Author: Anikina LV, Tolmacheva IA, Vikharev IuB, Grishko VV.
    Journal: Bioorg Khim; 2010; 36(2):259-64. PubMed ID: 20531485.
    Abstract:
    The immunotropic effect of the 2,3-seco derivatives of allobetulon, betulonic acid, and the methyl ester of betulonic acid were studied. It was found that the highest activity is shown by compounds with an oleanane fragment. The presence of a free C28-carboxyl group enhances the activity of lupeolic 2,3-seco derivatives. A significant contribution to the development of the immune response is introduced by a functional group at the C3 atom in the A ring - the C3-carboxy derivatives intensify the processes of antibody production and alter the number and ratio of leukocyte forms. It is shown that 2,3-seco-1-cyano-19beta,28-epoxy-18alpha-olean-3-oic acid stimulates humoral immunity with a positive influence on hematopoiesis.
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