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  • Title: [Primary sclerosing cholangitis].
    Author: Rasmussen HH, Fallingborg JF, Mortensen PB, Freund LG, Tage-Jensen U, Rasmussen SN.
    Journal: Ugeskr Laeger; 1991 May 20; 153(21):1487-91. PubMed ID: 2053198.
    Abstract:
    Primary sclerosing cholangitis (PSC) is an uncommon disorder of unknown etiology, characterized by chronic inflammation and fibrosis of the intra- and extrahepatic bile ducts. PSC is commonly associated with chronic inflammatory bowel disease, especially ulcerative colitis, and often in younger men with an extensive colitis. The diagnosis is made by endoscopic retrograde cholangiography. The characteristic findings are multiple strictures and dilatations of the intra- and extrahepatic bile ducts. Patients with PSC usually have a cholestatic biochemical profile. The liver biopsy findings are often non-specific. Different survivals in these patients have been described. However, asymptomatic patients seems to have a more favorable prognosis. The only curative treatment is liver transplantation.
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