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  • Title: [Association of cyclic adenosine monophosphate response element-binding protein gene and major depressive disorder].
    Author: Liu XH, Xu YF, Cui DH, Jiang SD, Qian YP, Yu SY, Jiang KD.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2010 Jun; 27(3):263-6. PubMed ID: 20533262.
    Abstract:
    OBJECTIVE: To investigate the association between single nucleotide polymorphisms (SNPs) in cyclic adenosine monophosphate response element-binding protein(CREB1) gene and major depressive disorder (MDD). METHODS: We recruited 105 parent-offspring trios of Chinese descent, extracted whole blood genomic DNA, and genotyped the SNPs in rs10932201 and rs6740584 loci. Single-marker transmission disequilibrium test (TDT), pairwise SNP linkage disequilibrium(LD) and haplotype-based TDT were performed. RESULTS: No significant association with MDD was observed for SNPs rs10932201 and rs6740584 (P=0.1004 and P=0.4986). However, there was strong positive association between the rs10932201-rs6740584 haplotype and MDD (P=0.00003241), and both haplotypes of A-C and A-T were significantly associated with MDD (P=0.020 and P=0.00022). CONCLUSION: The rs10932201-rs6740584 haplotype of the CREB1 gene may play an important role in the pathogenesis of MDD.
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