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  • Title: FAN (factor associated with neutral sphingomyelinase activation), a moonlighting protein in TNF-R1 signaling.
    Author: Montfort A, Martin PG, Levade T, Benoist H, Ségui B.
    Journal: J Leukoc Biol; 2010 Nov; 88(5):897-903. PubMed ID: 20534702.
    Abstract:
    TNF-α is a pleiotropic cytokine involved in the regulation of various biological effects, including cell survival and proliferation, cell differentiation, and cell death. Moreover, TNF-α triggers proinflammatory responses, essentially through its ability to promote the expression of various proinflammatory genes. Most of the biological effects initiated by TNF-α rely on its ability to bind to and activate TNF-R1. As a consequence, molecular complexes are being formed, resulting from the recruitment of multiple adaptor proteins to the intracellular TNF-R1 DD. The adaptor protein FAN constitutively binds to a proximal membrane domain of TNF-R1 called NSD. Herein, the role of FAN in TNF-α-induced cell signaling and biological responses is discussed.
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