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  • Title: [Meiotic inactivation of sex chromosomes in mammals].
    Author: Vas'kova EA, Pavlova SV, Shevchenko AI, Zakinian SM.
    Journal: Genetika; 2010 Apr; 46(4):437-47. PubMed ID: 20536013.
    Abstract:
    During meiosis, heteromorphic mammalian X and Y chromosomes in males undergo transcription silencing and form a compact structure, the XY body, containing specific modifications of the chromatin. In this review, we consider the dynamics of sex chromosome inactivation and discuss the suggestion that the paternally inherited X chromosome preserve inactivated state in zygote. This state results from meiotic silencing and is prone to imprinted inactivation, which his observed in mammalian females at early embryogenetic stages.
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