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  • Title: [Differentiation of human pancreatic endocrinocytes during embryogenesis].
    Author: Bobrik II, Davidenko LM.
    Journal: Arkh Anat Gistol Embriol; 1991 Feb; 100(2):42-8. PubMed ID: 2053879.
    Abstract:
    Time of appearance, succession and ultrastructural peculiarities of pancreatic endocrinocytes have been studied in human embryogenesis. A-insulocytes (the 7th-8th week) appear before B-endocrinocytes (the 9th-10th week). Before the 10th week A-insulocytes possess a higher degree of cytodifferentiation and development of the mechanisms necessary for hormones secretion. This should be taken into account at allotransplantation of the embryonal pancreas with the aim to correct insulin insufficiency.
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