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  • Title: Factors predictive of virological failure on atazanavir in 310 HIV-infected patients.
    Author: Lescure FX, Poirier JM, Meynard JL, Guiard-Schmid JB, Zouai O, Bonnard P, Slama L, Amiel C, Girard PM, Pialoux G.
    Journal: AIDS; 2010 Jun 19; 24(10):1593-5. PubMed ID: 20539093.
    Abstract:
    We examined factors associated with virological failure in 310 HIV-infected patients receiving atazanavir (ATV). Independent links were identified with virological failure under ATV: virological failure previous history (P = 0.006) and ATV underdosing (P = 0.04). A maintenance therapy was protective (P = 0.01). The optimal therapeutic ranges of ATV concentration were found to be from 300 ng/ml (or 180 for patients treated with maintenance therapy) to 650 ng/ml for C24 and from 1000 ng/ml (or 500 for patients treated with maintenance therapy) to 2000 ng/ml for C12.
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