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  • Title: Tenascin-W: an extracellular matrix protein associated with osteogenesis and cancer.
    Author: Martina E, Chiquet-Ehrismann R, Brellier F.
    Journal: Int J Biochem Cell Biol; 2010 Sep; 42(9):1412-5. PubMed ID: 20541035.
    Abstract:
    Tenascin-W was the last member of a family of four large extracellular matrix glycoproteins to be discovered. The original member of the tenascin family, tenascin-C, has been widely studied due to its association with asthma, fibrosis, infection, inflammation and cancer. Recent studies report multiple common features between tenascin-W and tenascin-C in terms of structure, expression and function, especially in the context of tumorigenesis. Furthermore, specific functions for tenascin-W in osteogenesis have been revealed. This review presents an update on our current knowledge concerning tenascin-W and discusses potential medical applications of this cancer-enriched extracellular matrix protein.
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