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  • Title: Characterization of and biomolecule immobilization on the biocompatible multi-walled carbon nanotubes generated by functionalization with polyamidoamine dendrimers.
    Author: Zhang B, Chen Q, Tang H, Xie Q, Ma M, Tan L, Zhang Y, Yao S.
    Journal: Colloids Surf B Biointerfaces; 2010 Oct 01; 80(1):18-25. PubMed ID: 20542415.
    Abstract:
    Polyamidoamine (PAMAM) dendrimers were covalently tethered onto the surface of multi-walled carbon nanotubes (MWCNTs). The morphology and dispersive properties of the MWCNT-PAMAM hybrids were characterized and the peripheral functional groups were identified. Cytotoxicity to human osteosarcoma MG-63 cells, and protein and DNA immobilization ability of the hybrids were evaluated in detail. The dendrimers were present on the surface of MWCNTs in high density. The MWCNT-PAMAM hybrids exhibited good dispersibility and stability in aqueous solution. We showed that the hybrids are biocompatible, with no obvious cytotoxicity at concentration <25 microgmL(-1) over 24h. They possess excellent biomolecule-immobilization ability (bovine serum albumin and 5'-Fam-CAAggTCgTgTAAAggTCAg-3' were used as models). The functionalization of MWCNTs with PAMAM dendrimers improved the biomolecule-immobilization ability 70-fold and simultaneously decreased the cellular toxicity by about 30%. It is expected that the MWCNT-PAMAM hybrids will find promising applications in biosensors and biomolecule delivery systems in gene or protein therapy.
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