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  • Title: [Alpha- and gamma-endorphin suppression of the chronotropic effects of exogenous acetylcholine].
    Author: Sokolova NA, Ashmarin IP.
    Journal: Nauchnye Doki Vyss Shkoly Biol Nauki; 1991; (1):102-6. PubMed ID: 2054414.
    Abstract:
    On the isolated frog heart alpha- and gamma-endorphins depressed the chronotropic effects of exogenous acetylcholine. Naloxone partially blocked the atropine-like action of alpha-, gamma-endorphins. The latent period of the reaction to the endorphin injection was about 20 min, the endorphin effect retained more than 1 h. The obtained data show that some opioids may act as "endogenous atropine".
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