These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [The dynamics of the chromatin transcription activity in cerebellar Purkinje cells after systemic circulatory arrest].
    Author: Avrushchenko MSh, Bul'chuk OV, Grigor'eva AV, Marshak TL, Iarygin VN.
    Journal: Biull Eksp Biol Med; 1991 Mar; 111(3):232-5. PubMed ID: 2054490.
    Abstract:
    Transcriptional activity of the dark and light Purkinje cells' nuclei in cerebellar cortex was studied in rats 1h, 24h, 96h and 7 days post a systemic blood circulation arrest. The study was performed with the help of the histoautoradiographic method of Moore. Some substantial changes in template activity of the Purkinje cells' chromatin were observed in the postresuscitation period. Those began to occur immediately after resuscitation and were of phasic nature. The shifts in transcriptional activity of nucleolar and extranucleolar chromatin appeared to be analogous and of similar dynamics. The changes were more significant in the light neurons than in the dark ones. It has been supposed that the changes revealed might be one of the causes of development of neurologic disorders induced by severe hypoxia.
    [Abstract] [Full Text] [Related] [New Search]