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  • Title: Effect of central cholinergic stimulation on regional cerebral blood flow in Alzheimer's disease.
    Author: Wilson K, Bowen D, Francis P, Tyrrell P.
    Journal: Br J Psychiatry; 1991 Apr; 158():558-62. PubMed ID: 2054572.
    Abstract:
    Patients with Alzheimer disease (AD) had reduced regional cerebral blood flow (rCBF) in the posterior parietotemporal region compared with controls, as determined with technetium-99m hexamethyl propyleneamine oxime and single photon emission tomography. Central cholinergic stimulation with physostigmine produced a focal increase in rCBF in the posterior parietotemporal region in the patients with AD but not in controls.
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