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  • Title: Comparison of SurePath® and ThinPrep® liquid-based cervical cytology using positive predictive value, atypical predictive value and total predictive value as performance indicators.
    Author: Wright PK, Marshall J, Desai M.
    Journal: Cytopathology; 2010 Dec; 21(6):374-8. PubMed ID: 20545727.
    Abstract:
    OBJECTIVE: Two liquid-based cytology (LBC) systems are in widespread use in the UK: ThinPrep® and SurePath®. A number of studies have now compared LBC with conventional cytology in cervical screening. However, to date, we are aware of no studies that have compared ThinPrep® with SurePath® LBC. As the selection and use of specific diagnostic systems in a laboratory has significant clinical and economic implications, there is a clear need to compare directly existing LBC technology. The objective of this study was to compare ThinPrep® with SurePath® LBC in a single cytology laboratory using performance indicators. METHODS: Data were collected for all cervical cytology samples processed at Manchester Cytology Centre over a 1-year period. ThinPrep® LBC was compared with SurePath® LBC using positive predictive value (PPV), atypical predictive value (APV) and total predictive value (TPV), reflecting outcome of cervical intraepithelial neoplasia (CIN) grade 2 or worse for high-grade dyskaryosis (PPV), low-grade dyskaryosis or borderline (atypical) cytology (APV) and all (total) abnormal cytology (TPV). RESULTS: 2287 (out of 56,467) (ThinPrep®) and 586 (out of 22,824) (SurePath®) samples showed borderline or worse cytology after exclusion criteria. PPV, APV and TPV were within acceptable ranges for both ThinPrep® and SurePath®. CONCLUSIONS: ThinPrep® and SurePath® were equivalent based on three performance indicators. We suggest that APV and TPV should be used as an adjunct to PPV and other methods of quality assurance for cervical screening.
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