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  • Title: Assessment of working memory in patients with mesial temporal lobe epilepsy associated with unilateral hippocampal sclerosis.
    Author: Tudesco Ide S, Vaz LJ, Mantoan MA, Belzunces E, Noffs MH, Caboclo LO, Yacubian EM, Sakamoto AC, Bueno OF.
    Journal: Epilepsy Behav; 2010 Jul; 18(3):223-8. PubMed ID: 20547107.
    Abstract:
    OBJECTIVE: The aim of the present study was to investigate whether working memory is impaired in mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS), a controversial and largely unexplored matter. METHODS: Twenty subjects with left MTLE-HS, 19 with right MTLE-HS, and 21 control right-handed subjects underwent neuropsychological assessment of episodic and semantic memory, executive functions, and specific working memory components. RESULTS: Left and right epileptogenic foci resulted in impairment of verbal and nonverbal episodic memory (verbal memory deficit greater in left MTLE-HS than in right MTLE-HS). In addition, patients with left MTLE-HS were impaired in learning paired associates, verbal fluency, and Trail Making. No differences were seen in the tests carried out to evaluate the working memory components (except visuospatial short-term memory in right MTLE-HS). CONCLUSION: In this study we did not detect reliable working memory impairment in patients with MTLE-HS with either a left or right focus in most tasks considered as tests of working memory components.
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