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  • Title: Pancreatic beta-cell signaling: toward better understanding of diabetes and its treatment.
    Author: Seino S, Shibasaki T, Minami K.
    Journal: Proc Jpn Acad Ser B Phys Biol Sci; 2010; 86(6):563-77. PubMed ID: 20551594.
    Abstract:
    Pancreatic beta-cells play a central role in the maintenance glucose homeostasis by secreting insulin, a key hormone that regulates blood glucose levels. Dysfunction of the beta-cells and/or a decrease in the beta-cell mass are associated closely with the pathogenesis and pathophysiology of diabetes mellitus, a major metabolic disease that is rapidly increasing worldwide. Clarification of the mechanisms of insulin secretion and beta-cell fate provides a basis for the understanding of diabetes and its better treatment. In this review, we discuss cell signaling critical for the insulin secretory function based on our recent studies.
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