These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: A histochemical and immunocytochemical study of hepatic copper and metallothionein in the pre- and post-natal rat.
    Author: Elmes ME, Haywood S, Jasani B.
    Journal: J Pathol; 1991 May; 164(1):83-7. PubMed ID: 2056392.
    Abstract:
    Histochemical and immunocytochemical methods to demonstrate copper, copper-associated protein, lipfuscin, and metallothionein were applied to the liver of fetal and neonatal rats (mid-term, pre-term, and 1, 3, and 7 days post-natal). Copper was detected only at 1 and 7 days post-natal. No copper-associated protein was found in any liver examined. Lipofuscin granules were present around term in small numbers but were most abundant at 7 days post-natal when the majority of them were also positive for copper. Metallothionein staining, both nuclear and cytoplasmic, was maximal at mid-term and became less intense with maturity. Although nuclear staining was always present, cytoplasmic staining varied between different areas of the liver. No marked difference in staining intensity was found between 3 and 7 days post-natal. There are marked differences in copper metabolism in the maturing liver between the rat and man.
    [Abstract] [Full Text] [Related] [New Search]