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  • Title: [Studies on ouinolone antibiotics. II. Synthesis and antibacterial activity of 7-aminoalkoxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3 -carbo xylic acids and their derivatives].
    Author: Yoshida T, Yamamoto Y, Yagi N, Takahasi Y, Yasuda S, Katoh H, Itoh Y.
    Journal: Yakugaku Zasshi; 1991 Jan; 111(1):19-31. PubMed ID: 2056441.
    Abstract:
    7-Aminoalkoxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3- carboxylic acid and their derivatives were synthesized and their antibacterial activities were evaluated. Among them, compounds having an alkyl group at alpha-position of the amino group were found to have in vitro and in vivo antibacterial activity comparable to that of ciprofloxacin. Structure-activity relationship of these compounds was also stated.
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