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  • Title: In vitro antifungal activities of isavuconazole and comparators against rare yeast pathogens.
    Author: Guinea J, Recio S, Escribano P, Peláez T, Gama B, Bouza E.
    Journal: Antimicrob Agents Chemother; 2010 Sep; 54(9):4012-5. PubMed ID: 20566770.
    Abstract:
    We compared the in vitro activities of isavuconazole, posaconazole, voriconazole, and fluconazole against Dipodascus capitatus (n = 21), Saccharomyces cerevisiae (n = 20), Rhodotorula mucilaginosa (n = 18), and Trichosporon spp. (n = 15). The MIC(50)s, MIC(90)s, and MIC ranges (in microg/ml) obtained using the CLSI M27-A3 procedure were as follows: isavuconazole, 0.125, 0.5, and < or = 0.015 to 2; posaconazole, 0.5, 2, and < or = 0.015 to > 16; voriconazole, 0.125, 2, and < or = 0.015 to 8; and fluconazole, 4, > 128, and < or = 0.125 to > 128. Isavuconazole showed potent activity against the isolates studied.
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