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  • Title: [Use of recombinant factor VII in Glanzmann thrombasthenia: a case report].
    Author: Chabchoub Ben Abdallah R, Trabelsi L, Ben Ameur S, Kammoun F, Boukédi A, Ben Salah M, Ben Hlima N, Mahfoudh A.
    Journal: Arch Pediatr; 2010 Jul; 17(7):1062-4. PubMed ID: 20570498.
    Abstract:
    Glanzmann thrombasthenia (TG) is a congenital platelet function disorder characterized by frequent and occasionally severe bleeding events. Treatment is based on platelet transfusion at the time of bleeding. We report a case of GT revealed in the neonatal period, a severe hemorrhagic syndrome refractory to transfusions, treated at the age of 6 years. Activated recombinant factor VII (Novoseven) injections were necessary. The advantages of recombinant activated factor VII in GT patients with platelet antibodies and/or platelet transfusions refractoriness are discussed.
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