These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Proteomic analysis of pubocervical fascia in women with and without pelvic organ prolapse and urodynamic stress incontinence.
    Author: Athanasiou S, Lymberopoulos E, Kanellopoulou S, Rodolakis A, Vlachos G, Antsaklis A.
    Journal: Int Urogynecol J; 2010 Nov; 21(11):1377-84. PubMed ID: 20571767.
    Abstract:
    INTRODUCTION AND HYPOTHESIS: This pilot study compares protein expression patterns in the pubocervical fascia of women with pelvic organ prolapse (POP) and stress urinary incontinence (SUI) and asymptomatic women with normal pelvic support. METHODS: Samples of pubocervical fascia were collected from four women with POP and SUI and from three asymptomatic (control) women. These were analyzed using two-dimensional electrophoresis and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. RESULTS: The expression levels of transgelin, smooth muscle gamma-actin, myosin light polypeptide 6, and alpha-1 antitrypsin precursor were more than twofold higher in patients than in controls. An additional five proteins were overexpressed (more than twofold) in patients, while three proteins were detected only in the patients. CONCLUSION: This pilot study is the first study to estimate changes in protein expression in the pubocervical fascia of human patients with POP. These changes could be related to the pathophysiology of POP.
    [Abstract] [Full Text] [Related] [New Search]