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  • Title: Lower airways may also be affected in asymptomatic patients with recent onset of allergic rhinitis.
    Author: Ciprandi G, Cirillo I, Klersy C.
    Journal: Laryngoscope; 2010 Jul; 120(7):1288-91. PubMed ID: 20578230.
    Abstract:
    OBJECTIVES/HYPOTHESIS: It is well known that there is a close association between allergic rhinitis (AR) and asthma, and AR is a strong risk factor for the onset of asthma. AR duration is significantly associated with a possible bronchial involvement. The aim of this study was to investigate the presence of possible spirometric abnormalities and bronchial hyperreactivity (BHR) in a large group of patients with recent onset of AR. STUDY DESIGN: Observational cross-sectional study. METHODS: A total of 1,539 AR patients were consecutively evaluated. Clinical examination, skin prick test, spirometry, and methacholine challenge were performed on all patients. RESULTS: : There were 362 (23%) patients with FEF(25-75) values <70% of predicted. The methacholine challenge was positive in 74.43% of patients, and 72.22% of the population presented a polysensitization. At multivariable analysis, an FEV(1) value lower than 92% of predicted, as well as increasing severity of BHR and polysensitization appeared to be independent predictors of a reduced FEF(25-75) value. CONCLUSIONS: This study shows that reduced FEF(25-75) values may be present in some patients with recent onset of AR. FEV(1) <92%, severity of BHR, and polysensitization may be considered risk factor for this phenomenon.
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