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  • Title: In vivo visualization of trophozoites in patients with amoebic colitis by using a newly developed endocytoscope.
    Author: Hosoe N, Kobayashi T, Kanai T, Bessho R, Takayama T, Inoue N, Imaeda H, Iwao Y, Kobayashi S, Mukai M, Ogata H, Hibi T.
    Journal: Gastrointest Endosc; 2010 Sep; 72(3):643-6. PubMed ID: 20579647.
    Abstract:
    BACKGROUND: The endocytoscopy system (ECS) is a new method to provide real-time super-magnifying microscopic imaging in vivo. Routine diagnosis of amebic colitis requires multiple tests that are both time consuming and costly. OBJECTIVE: To determine the feasibility of ECS to directly detect the amebic parasites in vivo. DESIGN: Prospective, single-center, pilot study. SETTING: Tertiary-care university hospital. PATIENTS: This study involved 5 patients who were suspected to have amebic colitis by conventional colonoscopy in our institute. INTERVENTIONS: A super-magnifying ECS with 450 x magnification. MAIN OUTCOME MEASUREMENTS: We compared ECS findings with those of conventional methods-serum antibody tests and histology of colon biopsy specimens. RESULTS: We successfully visualized the amebic trophozoites in all 5 cases. In contrast, 3 specimens had positive results on serology, and 3 had positive histology results on hematoxylin and eosin staining. LIMITATIONS: Pilot study with a limited number of patients. Findings were compared only with serology and histology findings. CONCLUSIONS: ECS would be a useful tool for the prompt diagnosis of amebic colitis via the real-time in vivo visualization of amebic trophozoites.
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