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  • Title: Coombs-positive autoimmune hemolytic anemia complicating ulcerative colitis. A case report.
    Author: Martinez P, Lambert M, Vanheuverzwyn R.
    Journal: Acta Gastroenterol Belg; 1991; 54(1):34-7. PubMed ID: 2058349.
    Abstract:
    We report the case of a 41-year-old woman with a 5-year history of left-sided ulcerative colitis easily controlled by sulfasalazine. She was admitted because of severe anemia, in the absence of any exacerbation of the colitis. A Coombs-positive (IgG type) hemolytic anemia was diagnosed and high-dose corticosteroid therapy was started, which proved to be unsuccessful. A splenectomy was then performed but the hemolytic anemia failed to subside. The patient was subsequently treated with a corticosteroid-azathioprine association with a sustained favourable effect on the anemia. The prevalence and pathophysiology of hemolytic anemia in ulcerative colitis is reviewed and a specific therapeutic approach is proposed.
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