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  • Title: Influence of no-donor (SIN-1) on functions of inflammatory cells.
    Author: Dembińska-Kieć A, Zmuda A, Marcinkiewicz J, Sinzinger H, Gryglewski RJ.
    Journal: Agents Actions; 1991 Jan; 32(1-2):37-40. PubMed ID: 2058467.
    Abstract:
    NO-donor SIN-1 (0.01-1.0 mM) dose-dependently inhibited the basal and FMLP (30.0 mM)-stimulated release of beta-glucuronidase from rat peritoneal leukocytes and antigen-specific stimulation of Interleukin-2 production by T-hybridomas. I-123 LDL binding to human lymphocytes was inhibited by Iloprost (1 mM) but activated by SIN-1 (0.3 mM). We conclude that beside the smooth muscle cells and platelets the blood inflammatory/immune cells are under the PGI2/NO control, however, the precise regulation as well as physiological importance need further investigation.
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