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  • Title: Analysis of gelatin plasma substitutes in blood based on detection of hydroxyproline derivatives.
    Author: Liu T, Zhanga G, Li S, Wang Y, Ma G, Su Z.
    Journal: Artif Cells Blood Substit Immobil Biotechnol; 2011 Feb; 39(1):19-25. PubMed ID: 20586664.
    Abstract:
    The gelatin plasma substitute is often polydisperse and heterogenous, making it difficult to determine the elimination rate and half-life in the body. In this study, one method was developed based on quantitative determination of hydroxyproline derivatives. Two plasma substitutes were prepared by succinylation and genipin-crosslinking, respectively. After transfusion, the blood samples were hydrolyzed and derivatized, and then analyzed by HPLC. A two-phase exponential association equation was used for fitting the time-concentration curves. The results indicated that this method could be used for quantitative determination of gelatin in blood, and the pharmacokinetic parameters such as elimination rate and half-life.
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