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  • Title: A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase.
    Author: Gattinoni S, Simone CD, Dallavalle S, Fezza F, Nannei R, Battista N, Minetti P, Quattrociocchi G, Caprioli A, Borsini F, Cabri W, Penco S, Merlini L, Maccarrone M.
    Journal: Bioorg Med Chem Lett; 2010 Aug 01; 20(15):4406-11. PubMed ID: 20591666.
    Abstract:
    A series of oxime carbamates have been identified as potent inhibitors of fatty acid amide hydrolase (FAAH), an important regulatory enzyme of the endocannabinoid signaling system. Kinetic analysis indicates that they behave as non-competitive, reversible inhibitors, and show remarkable selectivity for FAAH over the other components of the endocannabinoid system.
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