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  • Title: Cytotoxic bisbenzylisoquinoline alkaloids from the roots of Cyclea racemosa.
    Author: Wang JZ, Chen QH, Wang FP.
    Journal: J Nat Prod; 2010 Jul 23; 73(7):1288-93. PubMed ID: 20593839.
    Abstract:
    Six new bisbenzylisoquinoline alkaloids, racemosidines A-C (1-3) and racemosinines A-C (4-6), and four known compounds were isolated from the roots of Cyclea racemosa. Compound 1 is the first bisbenzylisoquinoline alkaloid reported that has diphenyl ether bridges at C-11/C-7' and C-8/C-12' and a benzyl-phenyl ether bridge at C-7/C-11'. Structures and absolute configurations of 1-6 were established by interpretation of spectroscopic data and confirmed by X-ray crystallographic analysis of representative compounds. Compounds 1-3 exhibited significant cytotoxicity against HCT-8 and BEL-7402 tumor cells, and compound 1 was also cytotoxic against A2780 tumor cells.
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