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  • Title: Drug targeting strategies for the treatment of inflammatory bowel disease: a mechanistic update.
    Author: Dahan A, Amidon GL, Zimmermann EM.
    Journal: Expert Rev Clin Immunol; 2010 Jul; 6(4):543-50. PubMed ID: 20594127.
    Abstract:
    The therapeutic management of inflammatory bowel disease (IBD) represents the perfect scenario for drug targeting to the site(s) of action. While existing formulation-based targeting strategies include rectal dosage forms and oral systems that target the colon by pH-, time-, microflora- and pressure-triggered drug release, novel approaches for site-specific delivery in IBD therapy will target the inflamed intestine per se rather than intestinal region. The purpose of this article is to present a mechanistic update on the strategies employed to achieve minimal systemic exposure accompanied by maximal drug levels in the inflamed intestinal tissue. The introduction of biological agents, micro/nanoparticulate carriers including liposomes, transgenic bacteria, and gene therapy opportunities are discussed, as well as the challenges remaining to be achieved in the targeted treatment of IBD.
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