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  • Title: More specific bands in the IgG western blot in sera from Scottish patients with suspected Lyme borreliosis.
    Author: Evans R, Mavin S, McDonagh S, Chatterton JM, Milner R, Ho-Yen DO.
    Journal: J Clin Pathol; 2010 Aug; 63(8):719-21. PubMed ID: 20595179.
    Abstract:
    AIMS: To identify further Western blot bands that may be specific in the diagnosis of Lyme borreliosis. METHODS: The Borrelia burgdorferi antibody profiles of 270 western blot positive patients and 241 western blot negative patients from 2008 were examined. RESULTS: 27 different non-specific bands were detected in both groups. Six of 27 (22%) of the non-specific bands were detected significantly more in the western blot positive patients compared to the western blot negative patients (20 kDa, p<0.0001; 28 kDa, p<0.002; 36 kDa, p<0.002; 37 kDa, p<0.007; 48 kDa, p<0.023; 56 kDa, p<0.028; two-tailed F test). CONCLUSION: Results suggest that the 20, 28 and 48 kDa bands should be regarded as specific.
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