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  • Title: ZnO nanorods/Au hybrid nanocomposites for glucose biosensor.
    Author: Wei Y, Li Y, Liu X, Xian Y, Shi G, Jin L.
    Journal: Biosens Bioelectron; 2010 Sep 15; 26(1):275-8. PubMed ID: 20598519.
    Abstract:
    ZnO nanorods/Au hybrid nanocomposites (ZnO/Au) with Au nanocrystals growing on the surface of ZnO nanorods were synthesized via a simple and facile hydrothermal route. The prepared ZnO/Au nanocomposites were characterized by X-ray diffraction (XRD), scanning electron microscope (SEM) and transmission electron microscopy (TEM) for the morphology study. The composites had a good electron transferring and biocompatibility. The glucose biosensor was fabricated by entrapping glucose oxidase (GOx) in this composite matrix using cross-linking method with glutaraldehyde and Nafion solutions. The proposed biosensor responded to glucose linearly over concentration range of 0.1-33.0 μM (R(2)=0.9956), and the detection limit was 10nM (S/N=3) at an operating potential of +0.55 V in pH 7.4 phosphate buffered solution (PBS). The biosensor exhibited a high and reproducible sensitivity, short response time (within 5s), good storage stability and high affinity to GOx (K(M)(app)=0.41 mM). The effects of electroactive interferents at the testing conditions can be negligible which showed a good selectivity of the biosensor. It is estimated that this ZnO/Au is an attractive material for the fabrication of efficient amperometric biosensors.
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