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  • Title: Comparison between evaluation methods for the anti-caries efficacy of monofluorophosphate-containing dentifrices.
    Author: Raven SJ, Schäfer F, Duckworth RM, Gilbert RJ, Parr TA.
    Journal: Caries Res; 1991; 25(2):130-7. PubMed ID: 2059974.
    Abstract:
    A comparison is described of three methods of preclinical assessment of potential anti-caries efficacy for topical fluoride treatments. Methods are compared using dentifrices containing 1,000, 1,500 and 2,500 ppm F as sodium monofluorophosphate (SMFP). These formulations have been shown elsewhere to give a statistically significant dose response of increasing anti-caries efficacy [Stephen et al., 1988]. An in situ enamel insert model, oral fluoride pharmacokinetics and F uptake to demineralised enamel are all shown to correlate with clinical efficacy for the test dentifrices studied.
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