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  • Title: Intracellular imaging with a graphene-based fluorescent probe.
    Author: Peng C, Hu W, Zhou Y, Fan C, Huang Q.
    Journal: Small; 2010 Aug 02; 6(15):1686-92. PubMed ID: 20602429.
    Abstract:
    Graphene is an increasingly important nanomaterial that has shown great promise in the area of nanotechnology. In this study, fluorescein-functionalized graphene oxide (GO) is synthesized via a polyethylene glycol (PEG) bridge and its application in intracellular imaging is explored. GO is an oxide form of graphene that provides an ideal platform to prepare graphene-based functional nanomaterials via chemical modification. The PEG bridge was introduced to prevent GO-induced quenching of conjugated fluorescein. The fluorescein-PEG-GO conjugate thus prepared exhibits excellent pH-tunable fluorescent properties and, more significantly, can be efficiently taken up by cells and serve as a fluorescent nanoprobe for intracellular imaging.
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