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  • Title: Surgical approaches to treatment of Parkinson's disease: Implications for speech function.
    Author: Murdoch BE.
    Journal: Int J Speech Lang Pathol; 2010 Oct; 12(5):375-84. PubMed ID: 20602579.
    Abstract:
    Although neurosurgical procedures have been reported to be successful in relieving many of the motor symptoms of Parkinson's disease (PD) (e.g., tremor, rigidity, bradykinesia) in the limb musculature, their effect on speech is much less consistent. This paper will review and evaluate reports in the literature on the effects of various surgical interventions for PD, including thalamotomy, pallidotomy, and DBS, on speech. In particular the paper will focus on the implications of these findings for one's understanding of the neurological control of the speech mechanism. As a foundation, contemporary models of the neuropathophysiology of PD and hypokinetic dysarthria will be outlined and explained. The various neurosurgical treatments for PD will be described and their theoretical underpinning discussed with regard to their proposed effects on subcortical and cortical motor control systems. Evidence suggestive of the need to reconsider contemporary thinking in relation to the neurology of speech and the need to differentiate it from limb neurology will be highlighted.
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